At present, there isn’t any particular, direct-acting antagonist to counteract the consequences of ketamine. Administration of hostile results focuses on supportive care. This entails guaranteeing satisfactory air flow, sustaining cardiovascular stability, and managing any emergent psychological disturbances. The first goal is to handle the signs offered by the person fairly than reversing the drug’s motion immediately.
Supportive care’s significance stems from ketamine’s complicated pharmacology. Whereas ketamine primarily acts as an NMDA receptor antagonist, it additionally interacts with opioid receptors, monoaminergic transporters, and voltage-sensitive calcium channels. This multifaceted mechanism of motion makes the event of a single, universally efficient reversal agent difficult. Traditionally, clinicians have relied on cautious monitoring and focused interventions to mitigate undesirable results.
